Chemokine (C-X-C motif) receptor 3 (CXCR3)
- Target Class
- GPCR
- Family
- Chemokine
- Official Symbol
- CXCR3
- Species
- Human
- Accession Number
- AY242128
- Alias Names
- C-X-C chemokine receptor type 3; CD182; CD183; CKR-L2; CMKAR3; CXC-R3; CXCR-3; G protein-coupled receptor 9; GPR9; IP-10 receptor; IP10 receptor; IP10-R; Mig receptor; Mig-R; MigR; chemokine (C-X-C motif) receptor 3; chemokine (C-X-C) receptor 3; interferon-inducible protein 10 receptor
- Background
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]
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Solution Portfolio
Related Family Members:
Chemokine
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| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
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