Chemokine (C-X-C motif) receptor 3 (CXCR3)

Target Class
Official Symbol
Accession Number
Alias Names
C-X-C chemokine receptor type 3; CD182; CD183; CKR-L2; CMKAR3; CXC-R3; CXCR-3; G protein-coupled receptor 9; GPR9; IP-10 receptor; IP10 receptor; IP10-R; Mig receptor; Mig-R; MigR; chemokine (C-X-C motif) receptor 3; chemokine (C-X-C) receptor 3; interferon-inducible protein 10 receptor
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]
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Solution Portfolio

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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family

Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0271C2
β-Arrestin U2OS Human 93-0271C3
Internalization U2OS Human 93-0661C3
cAMP CHO-K1 Human 95-0054C2
HEK 293 Human HTS003L
Chem-1 Human HTS003C
Assay Readout Background Species Assay Kit
cAMP CHO-K1 Human 95-0054E2CP2M
cAMP CHO-K1 Human 95-0054E2CP2L
β-Arrestin CHO-K1 Human 93-0271E2CP2M
β-Arrestin CHO-K1 Human 93-0271E2CP2L
Internalization U2OS Human 93-0661E3CP0M
Internalization U2OS Human 93-0661E3CP0L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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