Coagulation factor II (thrombin) receptor-like 1 (PAR2) (PAR2)
- Target Class
- GPCR
- Family
- Protease activated
- Official Symbol
- F2RL1
- Species
- Human
- Accession Number
- NM_005242.4
- Alias Names
- G protein-coupled receptor-11; G-protein coupled receptor 11; GPR11; PAR-2; PAR2; coagulation factor II (thrombin) receptor-like 1; coagulation factor II receptor-like 1; protease-activated receptor 2; proteinase-activated receptor 2; proteinase-activated receptor-2; thrombin receptor-like 1
- Background
Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence. [provided by RefSeq, Jul 2008]
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Solution Portfolio
Related Family Members:
Protease activated
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NHRscan |
GPCRscan |
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