Formylpeptide receptor-like 1 (FPR2/ALX)
- Target Class
- GPCR
- Family
- Formylpeptide
- Official Symbol
- FPRL1
- Species
- Human
- Accession Number
- AY225226
- Alias Names
- ALXR; FMLP-R-I; FMLP-R-II; FMLP-related receptor I; FMLPX; FPR2A; FPRH1; FPRH2; FPRL1; HM63; LXA4 receptor; LXA4R; N-formyl peptide receptor 2; RFP; formyl peptide receptor 2; formyl peptide receptor-like 1; lipoxin A4 receptor (formyl peptide receptor related)
- Background
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).
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Solution Portfolio
Related Family Members:
Formylpeptide
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