Hydroxycarboxylic acid receptor 2 (HCA2)
- Target Class
- GPCR
- Family
- Hydroxycarboxylic acid
- Official Symbol
- GPR109A
- Species
- Human
- Accession Number
- NM_177551
- Alias Names
- HCAR2; NIC1; G protein-coupled receptor 109A; G protein-coupled receptor HM74a; G-protein coupled receptor 109A; G-protein coupled receptor HM74A; GPR109A; HCA2; HM74a; HM74b; NIACR1; PUMAG; Puma-g; hydroxy-carboxylic acid receptor 2; hydroxycarboxylic acid receptor 2; niacin receptor 1; nicotinic acid receptor
- Background
Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5- methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
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Solution Portfolio
Related Family Members:
Hydroxycarboxylic acid
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| Assay Readout |
Background |
Species |
Cell Line |
| cAMP |
CHO-K1 |
Human |
95-0122C2 |
| β-Arrestin |
CHO-K1 |
Human |
93-0301C2 |
| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
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Available |
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