Hydroxycarboxylic acid receptor 2 (HCA2)

Target Class
Hydroxycarboxylic acid
Official Symbol
Accession Number
Alias Names
HCAR2; NIC1; G protein-coupled receptor 109A; G protein-coupled receptor HM74a; G-protein coupled receptor 109A; G-protein coupled receptor HM74A; GPR109A; HCA2; HM74a; HM74b; NIACR1; PUMAG; Puma-g; hydroxy-carboxylic acid receptor 2; hydroxycarboxylic acid receptor 2; niacin receptor 1; nicotinic acid receptor
Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5- methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
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Solution Portfolio

Related Family Members:

Hydroxycarboxylic acid

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family

Assay Readout Background Species Cell Line
cAMP CHO-K1 Human 95-0122C2
β-Arrestin CHO-K1 Human 93-0301C2
Assay Readout Background Species Assay Kit
cAMP CHO-K1 Human 95-0122E2CP2M
cAMP CHO-K1 Human 95-0122E2CP2L
β-Arrestin CHO-K1 Human 93-0301E2CP2M
β-Arrestin CHO-K1 Human 93-0301E2CP2L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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