Hydroxycarboxylic acid receptor 3 (HCA3)
- Target Class
- GPCR
- Family
- Hydroxycarboxylic acid
- Official Symbol
- GPR109B
- Species
- Human
- Accession Number
- NM_006018
- Alias Names
- HCAR3; NIC2; G protein-coupled receptor 109B; G-protein coupled receptor 109B; G-protein coupled receptor HM74; G-protein coupled receptor HM74B; GPR109B; GTP-binding protein; HCA3; HM74; PUMAG; Puma-g; hydroxy-carboxylic acid receptor 3; hydroxycarboxylic acid receptor 3; niacin receptor 2; nicotinic acid receptor 2; putative chemokine receptor
- Background
Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.
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Solution Portfolio
Related Family Members:
Hydroxycarboxylic acid
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| Assay Readout |
Background |
Species |
Cell Line |
| β-Arrestin |
CHO-K1 |
Human |
93-0791C2 |
| cAMP |
CHO-K1 |
Human |
95-0141C2 |
| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
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Available |
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