Metabotropic glutamate receptor 3 (MGlu3)

Target Class
GPCR
Family
Metabotropic glutamate
Official Symbol
GRM3
Species
Human
Accession Number
NM_000840.2
Alias Names
GLUR3; GPRC1C; MGLUR3; glutamate metabotropic receptor 3; glutamate receptor, metabotropic 3; mGlu3; metabotropic glutamate receptor 3
Background
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Metabotropic glutamate
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Assay Readout Background Species Cell Line
cAMP CHO-K1 Human 95-0137C2
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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