Chemokine-Like Receptor 1 (mCMKLR1)
- Target Class
- GPCR
- Family
- Chemokine
- Official Symbol
- mCMKLR1
- Species
- Mouse
- Accession Number
- NM_008153.2
- Alias Names
- ChemR23; DEZ; G-protein coupled receptor 27; G-protein coupled receptor DEZ; Gpcr27; chemerin receptor; chemokine receptor-like 1; chemokine-like receptor 1; mcmklr1
- Background
Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B (By similarity).
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Solution Portfolio
Related Family Members:
Chemokine
?
DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family
| Assay Readout |
Background |
Species |
Cell Line |
| β-Arrestin |
CHO-K1 |
Mouse |
93-0537C2 |
| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
| |
|
|
|
Available |
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