Find a Product

Sphingosine 1-phosphate receptor 1 (mS1P1)

Target Class
GPCR
Family
Lysophospholipid (S1P)
Official Symbol
mEDG1
Species
Mouse
Accession Number
NM_007901
Alias Names
AI849002; Edg1; Lpb1; S1P receptor 1; S1P receptor Edg-1; S1p; S1p1; endothelial differentiation G-protein coupled receptor 1; endothelial differentiation sphingolipid G-protein-coupled receptor 1; lysophospholipid receptor B1; sphingosine 1-phosphate receptor 1; sphingosine 1-phosphate receptor Edg-1; sphingosine-1-phosphate receptor 1
Background
This gene encodes a G-protein-coupled receptor bound by the lysophospholipid, sphingosine 1-phosphate. The gene product functions in endothelial cells and is involved in vascular and heart development. This receptor is highly expressed in T and B lymphocytes, and it plays a role in T cell and B cell export from peripheral lymphoid organs. This protein is bound and downregulated by FTY720, an exogenous immunosuppressant drug studied in mouse disease models for multiple sclerosis in humans. [provided by RefSeq, Jan 2010]
+ Show More

Solution Portfolio

Related Family Members:

Lysophospholipid (S1P)
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Mouse 93-0476C2
Assay Readout Background Species Assay Kit
β-Arrestin CHO-K1 Mouse 93-0476E2MCP4S
β-Arrestin CHO-K1 Mouse 93-0476E2MCP4M
β-Arrestin CHO-K1 Mouse 93-0476E2MCP4L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
The DiscoveRx Advantage:
Access your Target with Three Signaling Platforms