MAS-related GPR, member X1 (MRGPRX1)

Target Class
Class A Orphan
Official Symbol
Accession Number
Alias Names
G protein-coupled receptor MRGX1; G protein-coupled receptor SNSR3; GPCR; MAS-related GPR, member X1; MRGX1; SNSR4; mas-related G-protein coupled receptor member X1; sensory neuron-specific G-protein coupled receptor 3/4
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine- induced itch, in an histamine-independent manner.
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Solution Portfolio

Related Family Members:

Class A Orphan

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family

Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0919C2
Calcium RBL-2H3 Human 95-1019C11
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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