MAS-related GPR, member X1 (MRGPRX1)
- Target Class
- GPCR
- Family
- Class A Orphan
- Official Symbol
- MRGPRX1
- Species
- Human
- Accession Number
- NM_147199
- Alias Names
- G protein-coupled receptor MRGX1; G protein-coupled receptor SNSR3; GPCR; MAS-related GPR, member X1; MRGX1; SNSR4; mas-related G-protein coupled receptor member X1; sensory neuron-specific G-protein coupled receptor 3/4
- Background
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine- induced itch, in an histamine-independent manner.
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Solution Portfolio
Related Family Members:
Class A Orphan
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| Assay Readout |
Background |
Species |
Cell Line |
| β-Arrestin |
CHO-K1 |
Human |
93-0919C2 |
| Calcium |
RBL-2H3 |
Human |
95-1019C11 |
| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
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Available |
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