Platelet activating receptor (PAF)
- Target Class
- GPCR
- Family
- Platelet-activating factor
- Official Symbol
- PTAFR
- Species
- Human
- Accession Number
- NM_000952.4
- Alias Names
- PAF-R; PAFR; platelet-activating factor receptor
- Background
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
+ Show More
Solution Portfolio
Related Family Members:
Platelet-activating factor
?
DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family
| Assay Readout |
Background |
Species |
Cell Line |
| cAMP |
CHO-K1 |
Human |
95-0091C2 |
| β-Arrestin |
CHO-K1 |
Human |
93-0236C2 |
| Internalization |
U2OS |
Human |
93-0680C3 |
| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
| |
|
|
|
Available |
|
The DiscoveRx Advantage:
Access your Target with Three Signaling Platforms