Parathyroid hormone receptor 1 (PTH1)
- Target Class
- GPCR
- Family
- Parathyroid hormone
- Official Symbol
- PTHR1
- Species
- Human
- Accession Number
- AY449732
- Alias Names
- PTH1R; PFE; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; PTHR; PTHR1; parathyroid hormone 1 receptor; parathyroid hormone receptor 1; parathyroid hormone/parathyroid hormone-related peptide receptor; parathyroid hormone/parathyroid hormone-related protein receptor; seven transmembrane helix receptor
- Background
The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]
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Solution Portfolio
Related Family Members:
Parathyroid hormone
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family
| Assay Readout |
Background |
Species |
Cell Line |
| cAMP |
CHO-K1 |
Human |
95-0118C2 |
| β-Arrestin |
CHO-K1 |
Human |
93-0315C2 |
| Internalization |
U2OS |
Human |
93-0770C3 |
| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
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Available |
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