Prostanoid DP2 receptor (rGPR44)

Target Class
Official Symbol
Accession Number
Alias Names
CD294; CRTH2; DL1R; DP2; G protein-coupled receptor 44; G-protein coupled receptor 44; GPR44; chemoattractant receptor homologous molecule expressed on T helper type 2 cells; chemoattractant receptor-homologous molecule expressed on TH2 cells; prostaglandin D2 receptor 2; putative G-protein coupled receptor 44
Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca2+ mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses
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Solution Portfolio

Related Family Members:


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Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Rat 93-0580C2
Assay Readout Background Species Assay Kit
β-Arrestin CHO-K1 Rat 93-0580E2RCP2M
β-Arrestin CHO-K1 Rat 93-0580E2RCP2L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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