Nudix hydrolase 1 (MTH1)

Target Class
Official Symbol
Accession Number
Alias Names
MTH1;NUDT1, nudix hydrolase 1; 7,8-dihydro-8-oxoguanine triphosphatase; 2-hydroxy-dATP diphosphatase; 8-oxo-dGTPase; Nucleoside diphosphate-linked moiety X motif 1; Nudix motif 1
MTH1 is a hydrolase that removes oxidized deoxynucleoside triphosphates (dNTPs) from the cellular dNTP pool by hydrolyzing the triphosphate to a monophosphate. Oxidized dNTPs, including 8-oxodGTP, once incorporated into DNA can cause mutations and DNA damage detrimental to cell viability. Several publications suggest that tumor cells are more dependent on MTH1 activity than normal cells and, further, that MTH1 is a novel druggable target for anticancer therapy. As detailed below, the human MTH1 construct provided in this kit is a truncated version of the full-length protein (N-terminus truncated by 41 amino acids) that includes the entire hydrolase domain. This construct is based on a published MTH1 crystal structure (PDB ID: 4C9X).
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Solution Portfolio

Related Group Members: Hydrolase

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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan