Targets / Kinase / AMPK-alpha1

protein kinase, AMP-activated, alpha 2 catalytic subunit (AMPK-alpha1)

Target Class
Kinase
Family
CAMK
Official Symbol
PRKAA1
Entrez Gene ID
5562
Species
Human
Accession Number
BAA36547.1
Alias Names
5'-AMP-activated protein kinase catalytic subunit alpha-1; 5'-AMP-activated protein kinase, catalytic alpha-1 chain; AMP -activate kinase alpha 1 subunit; AMP-activated protein kinase, catalytic, alpha-1; AMPK; AMPK alpha 1; AMPK subunit alpha-1; AMPKa1; protein kinase, AMP-activated, alpha 1 catalytic subunit; tau-protein kinase PRKAA1
Background
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
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Related Group Members: CAMK
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