Targets / Kinase / AXL
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AXL receptor tyrosine kinase (AXL)

Target Class
Kinase
Family
Receptor tyrosine kinase
Official Symbol
AXL
Species
Human
Accession Number
NM_021913.3
Alias Names
AXL oncogene; AXL receptor tyrosine kinase; AXL transforming sequence/gene; JTK11; UFO; oncogene AXL; tyrosine-protein kinase receptor UFO
Background
The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Group Members: Receptor tyrosine kinase
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Cell Lines
Assay Measures Background Species Cell Line
Receptor Phosphorylation U2OS Human 93-1105C3
LeadHunter Screening & Profiling Services
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available Available