Targets / Kinase / BTK
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Bruton agammaglobulinemia tyrosine kinase (BTK)

Target Class
Kinase
Family
Cytosolic tyrosine kinase
Official Symbol
BTK
Species
Human
Accession Number
NM_000061.2
Alias Names
AGMX1; AT; ATK; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; IMD1; PSCTK1; XLA; agammaglobulinaemia tyrosine kinase; dominant-negative kinase-deficient Brutons tyrosine kinase; tyrosine-protein kinase BTK; tyrosine-protein kinase BTK isoform (lacking exon 14)
Background
The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. [provided by RefSeq, Nov 2008]
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Solution Portfolio

Related Group Members: Cytosolic tyrosine kinase
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Cell Lines
Assay Measures Background Species Cell Line
Intracellular Binding A549 96-0056C15
Targeted Degradation K562 Human 91-1005C042
Ready to Use eXpress Kits
Assay Measures Background Species Assay Kit
Intracellular Binding A549 96-0056E15CP0M
Intracellular Binding A549 96-0056E15CP0L
LeadHunter Screening & Profiling Services
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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