megakaryocyte-associated tyrosine kinase (CTK)

Target Class
Kinase
Family
TK
Official Symbol
MATK
Entrez Gene ID
4145
Species
Human
Accession Number
NP_002369.2
Alias Names
CHK; CSK homologous kinase; CTK; Csk-homologous kinase; Csk-type protein tyrosine kinase; HHYLTK; HYL; HYL tyrosine kinase; HYLTK; Lsk; hematopoietic consensus tyrosine-lacking kinase; hydroxyaryl-protein kinase; leukocyte carboxyl-terminal src kinase related; megakaryocyte-associated tyrosine kinase; megakaryocyte-associated tyrosine-protein kinase; protein kinase HYL; tyrosine kinase MATK; tyrosine-protein kinase CTK; tyrosylprotein kinase
Background
The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
+ Show More


Solution Portfolio

Related Group Members: TK
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available