Targets / Kinase / EGFR

epidermal growth factor receptor (EGFR)

Target Class
Kinase
Family
TK
Official Symbol
EGFR
Entrez Gene ID
1956
Species
Human
Accession Number
NP_005219.2
Alias Names
ERBB; ERBB1; HER1; PIG61; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; epidermal growth factor receptor; epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog); mENA; proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1
Background
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
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Solution Portfolio

Related Group Members: TK
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Cell Lines
Assay Measures Background Species Cell Line
EGFR/EGFR Dimerization U2OS Human 93-0989C3
EGFR/ErbB2 Dimerization U2OS Human 93-1051C3
Dimerization U2OS Human 93-1125C3
Ready to Use eXpress Kits
Assay Measures Background Species Assay Kit
EGFR/EGFR Dimerization U2OS Human 93-0989E3CP5M
EGFR/EGFR Dimerization U2OS Human 93-0989E3CP5L
EGFR/ErbB2 Dimerization U2OS Human 93-1051E3CP14M
EGFR/ErbB2 Dimerization U2OS Human 93-1051E3CP14L
Ready to Use Bioassay Kits
Assay Qualified With Assay Measures Background Species Assay Kit
‎Vectibix® EGFR/ErbB2 Dimerization U2OS Human 93-1051Y3-00093
‎Vectibix® EGFR/ErbB2 Dimerization U2OS Human 93-1051Y3-00094
LeadHunter Screening & Profiling Services
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available