Targets / Kinase / ErbB4
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erb-b2 receptor tyrosine kinase 4

Target Class
Kinase
Family
Receptor Tyrosine Kinase
Official Symbol
ErbB4
Species
Human
Accession Number
NM_005235.2
Alias Names
ERBB4; HER4; MGC138404; p180erbB4
Background
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Group Members: Receptor Tyrosine Kinase
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Cell Lines
Assay Measures Background Species Cell Line
Receptor Phosphorylation U2OS Human 93-0465C3
ErbB2/ErbB4 Dimerization U2OS Human 93-0960C3
ErbB4/ErbB4 Dimerization U2OS Human 93-0961C3
Ready to Use eXpress Kits
Assay Measures Background Species Assay Kit
ErbB4/ErbB4 Dimerization U2OS Human 93-0961E3CP5M
ErbB4/ErbB4 Dimerization U2OS Human 93-0961E3CP5L
ErbB2/ErbB4 Dimerization U2OS Human 93-0960E3CP5M
ErbB2/ErbB4 Dimerization U2OS Human 93-0960E3CP5L
LeadHunter Screening & Profiling Services
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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