Growth hormone receptor (GHR-JAK1)

Target Class
Cytosolic Tyrosine Kinase
Official Symbol
Accession Number
Alias Names
GH receptor; GHBP; growth hormone binding protein; growth hormone receptor; serum binding protein; somatotropin receptor
This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
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Solution Portfolio

Related Group Members: Cytosolic Tyrosine Kinase

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family

Assay Measures Background Species Cell Line
Receptor Phosphorylation U2OS Human 93-0756C3
Assay Measures Background Species Assay Kit
Receptor Phosphorylation U2OS 93-0756E3CP0M
Receptor Phosphorylation U2OS 93-0756E3CP0L
Assay Qualified With Assay Measures Background Species Assay Kit
hGH SH2 Recruitment U2OS Human 93-0756Y3-00023
hGH SH2 Recruitment U2OS Human 93-0756Y3-00024
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan