Targets / Kinase / LKB1

serine/threonine kinase 11 (LKB1)

Target Class
Kinase
Family
CAMK
Official Symbol
STK11
Entrez Gene ID
6794
Species
Human
Accession Number
NP_000446.1
Alias Names
LKB1; PJS; hLKB1; liver kinase B1; polarization-related protein LKB1; renal carcinoma antigen NY-REN-19; serine/threonine kinase 11; serine/threonine kinase 11 (Peutz-Jeghers syndrome); serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1; serine/threonine-protein kinase STK11
Background
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
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Related Group Members: CAMK
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