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mitogen-activated protein kinase kinase kinase 3 (MAP3K3)

Target Class
Kinase
Family
STE
Official Symbol
MAP3K3
Entrez Gene ID
4215
Species
Human
Accession Number
NP_002392.2
Alias Names
MAP/ERK kinase kinase 3; MAPK/ERK kinase kinase 3; MAPKKK3; MEK kinase 3; MEKK 3; MEKK3; mitogen-activated protein kinase kinase kinase 3
Background
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
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Related Group Members: STE
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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