Targets / Kinase / MAP4K2

mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2)

Target Class
Kinase
Family
STE
Official Symbol
MAP4K2
Entrez Gene ID
5871
Species
Human
Accession Number
NP_004570.2
Alias Names
B lymphocyte serine/threonine protein kinase; BL44; GC kinase; GCK; MAPK/ERK kinase kinase kinase 2; MEK kinase kinase 2; MEKKK 2; RAB8IP; Rab8 interacting protein; b lymphocyte serine/threonine-protein kinase; germinal center kinase; germinal centre kinase (GC kinase); mitogen-activated protein kinase kinase kinase kinase 2; rab8-interacting protein
Background
The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. [provided by RefSeq, Jul 2008]
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