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mitogen-activated protein kinase kinase 3 (MEK3)

Target Class
Kinase
Family
STE
Official Symbol
MAP2K3
Entrez Gene ID
5606
Species
Human
Accession Number
NP_002747.2
Alias Names
MAP kinase kinase 3; MAPK/ERK kinase 3; MAPKK 3; MAPKK3; MEK 3; MEK3; MKK3; PRKMK3; SAPK kinase 2; SAPKK-2; SAPKK2; dual specificity mitogen-activated protein kinase kinase 3; mitogen-activated protein kinase kinase 3; stress-activated protein kinase kinase 2
Background
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
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