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mitogen-activated protein kinase kinase 5 (MEK5)

Target Class
Kinase
Family
STE
Official Symbol
MAP2K5
Entrez Gene ID
5607
Species
Human
Accession Number
NP_660143.1
Alias Names
HsT17454; MAP kinase kinase 5; MAP kinase kinase MEK5b; MAPK/ERK kinase 5; MAPKK 5; MAPKK5; MEK 5; MEK5; PRKMK5; dual specificity mitogen-activated protein kinase kinase 5; mitogen-activated protein kinase kinase 5
Background
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]
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Related Group Members: STE
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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