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mitogen-activated protein kinase kinase 7 (MKK7)

Target Class
Kinase
Family
STE
Official Symbol
MAP2K7
Entrez Gene ID
5609
Species
Human
Accession Number
NP_660186.1
Alias Names
JNK-activating kinase 2; JNKK 2; Jnkk2; MAP kinase kinase 7; MAPK/ERK kinase 7; MAPKK 7; MAPKK7; MEK 7; MKK7; PRKMK7; SAPK kinase 4; SAPKK-4; SAPKK4; c-Jun N-terminal kinase kinase 2; dual specificity mitogen-activated protein kinase kinase 7; mitogen-activated protein kinase kinase 7; stress-activated protein kinase kinase 4
Background
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined. [provided by RefSeq, Jul 2008]
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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