mitogen-activated protein kinase kinase 7 (MKK7)

Target Class
Official Symbol
Entrez Gene ID
Accession Number
Alias Names
JNK-activating kinase 2; JNKK 2; Jnkk2; MAP kinase kinase 7; MAPK/ERK kinase 7; MAPKK 7; MAPKK7; MEK 7; MKK7; PRKMK7; SAPK kinase 4; SAPKK-4; SAPKK4; c-Jun N-terminal kinase kinase 2; dual specificity mitogen-activated protein kinase kinase 7; mitogen-activated protein kinase kinase 7; stress-activated protein kinase kinase 4
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined. [provided by RefSeq, Jul 2008]
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Related Group Members: STE

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