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mitogen-activated protein kinase kinase kinase 11 (MLK3)

Target Class
Kinase
Family
TKL
Official Symbol
MAP3K11
Entrez Gene ID
4296
Species
Human
Accession Number
NP_002410.1
Alias Names
MEKK11; MLK-3; MLK3; PTK1; SH3 domain-containing proline-rich kinase; SPRK; mitogen-activated protein kinase kinase kinase 11; mixed lineage kinase 3; protein-tyrosine kinase PTK1; src-homology 3 domain-containing proline-rich kinase
Background
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]
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Related Group Members: TKL
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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