Targets / Kinase / MRCKA

CDC42 binding protein kinase alpha (DMPK-like) (MRCKA)

Target Class
Kinase
Family
AGC
Official Symbol
CDC42BPA
Entrez Gene ID
8476
Species
Human
Accession Number
NP_003598.2
Alias Names
CDC42 binding protein kinase alpha (DMPK-like); CDC42 binidng protein kinase beta; CDC42-binding protein kinase alpha (DMPK-like); DMPK-like alpha; MRCK; MRCK alpha; MRCKA; PK428; myotonic dystrophy kinase-related CDC42-binding kinase alpha; myotonic dystrophy kinase-related CDC42-binding protein kinase alpha; myotonic dystrophy protein kinase-like alpha; ser-thr protein kinase PK428; ser-thr protein kinase related to the myotonic dystrophy protein kinase; serine/threonine-protein kinase MRCK alpha
Background
The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq, Jul 2008]
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