Targets / Kinase / MST1R

macrophage stimulating 1 receptor (c-met-related tyrosine kinase) (MST1R)

Target Class
Kinase
Family
TK
Official Symbol
MST1R
Entrez Gene ID
4486
Species
Human
Accession Number
NP_002438.2
Alias Names
CD136; CDw136; MSP receptor; PTK8; PTK8 protein tyrosine kinase 8; RON; RON variant E2E3; c-met-related tyrosine kinase; macrophage stimulating 1 receptor (c-met-related tyrosine kinase); macrophage-stimulating protein receptor; p185-Ron; soluble RON variant 1; soluble RON variant 2; soluble RON variant 3; soluble RON variant 4
Background
This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcript variants encoding different isoforms with different structural and biochemical properties have been described (PMID:8816464). [provided by RefSeq, Oct 2011]
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