Targets / Kinase / MTOR

mechanistic target of rapamycin (serine/threonine kinase) (MTOR)

Target Class
Kinase
Family
Atypical
Official Symbol
MTOR
Entrez Gene ID
2475
Species
Human
Accession Number
NP_004949.1
Alias Names
FK506 binding protein 12-rapamycin associated protein 1; FK506 binding protein 12-rapamycin associated protein 2; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP-rapamycin associated protein; FKBP12-rapamycin complex-associated protein 1; FRAP; FRAP1; FRAP2; RAFT1; RAPT1; mammalian target of rapamycin; mechanistic target of rapamycin (serine/threonine kinase); rapamycin and FKBP12 target 1; rapamycin associated protein FRAP2; rapamycin target protein 1; serine/threonine-protein kinase mTOR
Background
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]
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