Targets / Kinase / NEK3

NIMA (never in mitosis gene a)-related kinase 3 (NEK3)

Target Class
Kinase
Family
Other
Official Symbol
NEK3
Entrez Gene ID
4752
Species
Human
Accession Number
NP_002489.1
Alias Names
HSPK 36; HSPK36; NIMA (never in mitosis gene a)-related kinase 3; glycogen synthase A kinase; hydroxyalkyl-protein kinase; never in mitosis A-related kinase 3; nimA-related protein kinase 3; phosphorylase B kinase kinase; serine/threonine-protein kinase Nek3
Background
This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
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