Targets / Kinase / NEK9

NIMA (never in mitosis gene a)-related kinase 9 (NEK9)

Target Class
Kinase
Family
Other
Official Symbol
NEK9
Entrez Gene ID
91754
Species
Human
Accession Number
NP_149107.4
Alias Names
NERCC; NERCC1; NIMA (never in mitosis gene a)- related kinase 9; NIMA-related kinase Nek8; Nek8; nercc1 kinase; never in mitosis A-related kinase 9; nimA-related kinase 8; nimA-related protein kinase 9; serine/threonine-protein kinase Nek9
Background
Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively.
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