Targets / Kinase / PIP5K1C

phosphatidylinositol-4-phosphate 5-kinase, type I, gamma (PIP5K1C)

Target Class
Kinase
Family
Lipid
Official Symbol
PIP5K1C
Entrez Gene ID
23396
Species
Human
Accession Number
NP_036530.1
Alias Names
Human homolog of mouse phosphatidylinositol-4-phosphate 5-kinase I-gamma; LCCS3; PIP5K-GAMMA; PIP5K1-gamma; PIP5Kgamma; PIPKIg_v4; diphosphoinositide kinase; phosphatidylinositol-4-phosphate 5-kinase type-1 gamma; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma; ptdIns(4)P-5-kinase 1 gamma; type I PIP kinase
Background
This locus encodes a type I phosphatidylinositol 4-phosphate 5-kinase. The encoded protein catalyzes phosphorylation of phosphatidylinositol 4-phosphate, producing phosphatidylinositol 4,5-bisphosphate. This enzyme is found at synapses and has been found to play roles in endocytosis and cell migration. Mutations at this locus have been associated with lethal congenital contractural syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Sep 2010]
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Related Group Members: Lipid
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