Targets / Kinase / PKMYT1

protein kinase, membrane associated tyrosine/threonine 1 (PKMYT1)

Target Class
Kinase
Family
Other
Official Symbol
PKMYT1
Entrez Gene ID
9088
Species
Human
Accession Number
NP_872629.1
Alias Names
MYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; myt1 kinase; protein kinase, membrane associated tyrosine/threonine 1
Background
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Protein kinases AKT1/PKB and PLK (Polo-like kinase) have been shown to phosphorylate and regulate the activity of this kinase. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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