Targets / Kinase / PKN1

protein kinase N1 (PKN1)

Target Class
Kinase
Family
AGC
Official Symbol
PKN1
Entrez Gene ID
5585
Species
Human
Accession Number
NP_998725.1
Alias Names
DBK; PAK-1; PAK1; PKN; PKN-ALPHA; PRK1; PRKCL1; protease-activated kinase 1; protein kinase C-like 1; protein kinase C-like PKN; protein kinase C-related kinase 1; protein kinase N1; protein kinase PKN-alpha; protein-kinase C-related kinase 1; serine-threonine kinase N; serine-threonine protein kinase N; serine/threonine protein kinase N; serine/threonine-protein kinase N1
Background
The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
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