Targets / Kinase / PRKD3

protein kinase D3 (PRKD3)

Target Class
Kinase
Family
CAMK
Official Symbol
PRKD3
Entrez Gene ID
23683
Species
Human
Accession Number
NP_005804.1
Alias Names
EPK2; PKC-NU; PKD3; PRKCN; nPKC-NU; protein kinase C nu type; protein kinase C, nu; protein kinase D3; protein kinase EPK2; protein-serine/threonine kinase; serine/threonine-protein kinase D3
Background
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. This kinase can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phopholipase C gamma and the involvement of other PKC family members. [provided by RefSeq, Jul 2008]
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Related Group Members: CAMK
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