Targets / Kinase / PRLR-JAK2
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Prolactin receptor (PRLR)

Target Class
Kinase
Family
Cytosolic Tyrosine Kinase
Official Symbol
PRLR-JAK2
Species
Human
Accession Number
NM_000949
Alias Names
PRL-R; hPRL receptor; hPRLrI; prolactin receptor; secreted prolactin binding protein
Background
This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]
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Solution Portfolio

Related Group Members: Cytosolic Tyrosine Kinase
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Cell Lines
Assay Measures Background Species Cell Line
Receptor Phosphorylation U2OS Human 93-0687C3
Ready to Use eXpress Kits
Assay Measures Background Species Assay Kit
Receptor Phosphorylation U2OS Human 93-0687E3CP0M
Receptor Phosphorylation U2OS Human 93-0687E3CP0L
LeadHunter Screening & Profiling Services
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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