Targets / Kinase / STK39

serine/threonine kinase 39 (STK39)

Target Class
Kinase
Family
STE
Official Symbol
STK39
Entrez Gene ID
27347
Species
Human
Accession Number
NP_037365.2
Alias Names
DCHT; PASK; SPAK; STE20/SPS1 homolog; STE20/SPS1-related proline-alanine-rich protein kinase; Ste20-like protein kinase; proline-alanine-rich STE20-related kinase; serine threonine kinase 39; serine threonine kinase 39 (STE20/SPS1 homolog, yeast); serine/threonine-protein kinase 39; small intestine SPAK-like kinase; ste-20-related kinase
Background
This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008]
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Related Group Members: STE
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