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transforming growth factor, beta receptor II (70/80kDa) (TGFBR2)

Target Class
Kinase
Family
TKL
Official Symbol
TGFBR2
Entrez Gene ID
7048
Species
Human
Accession Number
NP_003233.4
Alias Names
AAT3; FAA3; LDS1B; LDS2B; MFS2; RIIC; TAAD2; TGF-beta receptor type II; TGF-beta receptor type IIB; TGF-beta receptor type-2; TGF-beta type II receptor; TGFR-2; TGFbeta-RII; tbetaR-II; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II (70-80kD); transforming growth factor, beta receptor II (70/80kDa); transforming growth factor, beta receptor II (70/80kDa) isoform 1; transforming growth factor, beta receptor II (70/80kDa) isoform 2; transforming growth factor-beta receptor type II
Background
This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Group Members: TKL
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Measures Background Species Cell Line
TGFBR1/TGFBR2 Dimerization U2OS Human 93-0889C3
Assay Measures Background Species Assay Kit
TGFBR1/TGFBR2 Dimerization U2OS Human 93-0889E3CP5S
TGFBR1/TGFBR2 Dimerization U2OS Human 93-0889E3CP5M
TGFBR1/TGFBR2 Dimerization U2OS Human 93-0889E3CP5L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available