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TTK protein kinase (TTK)

Target Class
Kinase
Family
Other
Official Symbol
TTK
Entrez Gene ID
7272
Species
Human
Accession Number
NP_003309.2
Alias Names
CT96; ESK; MPS1; MPS1L1; PYT; TTK protein kinase; cancer/testis antigen 96; dual specificity protein kinase TTK; monopolar spindle 1-like 1; phosphotyrosine picked threonine kinase; phosphotyrosine picked threonine-protein kinase
Background
This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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