Targets / Kinase / ULK1

unc-51-like kinase 1 (ULK1)

Target Class
Kinase
Family
Other
Official Symbol
ULK1
Entrez Gene ID
8408
Species
Human
Accession Number
NP_003556.1
Alias Names
ATG1; ATG1 autophagy related 1 homolog; ATG1A; UNC51; Unc51.1; autophagy-related protein 1 homolog; hATG1; serine/threonine-protein kinase ULK1; unc-51 (C. elegans)-like kinase 1; unc-51-like kinase 1 (C. elegans)
Background
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation.
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