Targets / Kinase / WEE2

WEE1 homolog 2 (WEE2)

Target Class
Kinase
Family
Other
Official Symbol
WEE2
Entrez Gene ID
494551
Species
Human
Accession Number
NP_001099028.1
Alias Names
WEE1 homolog 2 (S. pombe); WEE1B; wee1-like protein kinase 1B; wee1-like protein kinase 2; wee1B kinase
Background
Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity).
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