Gene Symbol |
Position |
Subposition |
Mutant |
AAK1 |
DFG region, Hinge binding region |
DFG-1, Hinge2 |
No |
AKT1 |
DFG region |
DFG+2 |
No |
AKT2 |
DFG region |
DFG+2 |
No |
AKT3 |
DFG region |
DFG+2 |
No |
BIKE |
DFG region, Hinge binding region |
DFG-1, Hinge2 |
No |
BLK |
Hinge binding region |
Hinge6 |
No |
BMX |
Hinge binding region |
Hinge6 |
No |
BRAF |
Hinge binding region |
Hinge2 |
No |
BRAF(V600E) |
Hinge binding region |
Hinge2 |
Yes |
BTK |
Hinge binding region |
Hinge6 |
No |
CDK5 |
Hinge binding region |
Hinge2 |
No |
CDK9 |
Hinge binding region |
Hinge2 |
No |
CDKL1 |
DFG region, Hinge binding region |
DFG-1, Hinge2 |
No |
CDKL2 |
DFG region |
DFG-1 |
No |
CDKL3 |
DFG region |
DFG-1 |
No |
CDKL5 |
DFG region |
DFG-1 |
No |
CHEK1 |
Hinge binding region |
Hinge2 |
No |
CSF1R |
Hinge binding region |
Hinge2, Hinge3 |
No |
CSF1R-autoinhibited |
Hinge binding region |
Hinge2 |
No |
DMPK |
DFG region |
DFG+2 |
No |
DMPK2 |
DFG region |
DFG+2 |
No |
EGFR |
Hinge binding region |
Hinge6 |
No |
EGFR(E746-A750del) |
Hinge binding region |
Hinge6 |
Yes |
EGFR(G719C) |
Hinge binding region |
Hinge6 |
Yes |
EGFR(G719S) |
Hinge binding region |
Hinge6 |
Yes |
EGFR(L747-E749del, A750P) |
Hinge binding region |
Hinge6 |
Yes |
EGFR(L747-S752del, P753S) |
Hinge binding region |
Hinge6 |
Yes |
EGFR(L747-T751del,Sins) |
Hinge binding region |
Hinge6 |
Yes |
EGFR(L858R) |
Hinge binding region |
Hinge6 |
Yes |
EGFR(L858R,T790M) |
Hinge binding region |
Hinge6 |
Yes |
EGFR(L861Q) |
Hinge binding region |
Hinge6 |
Yes |
EGFR(S752-I759del) |
Hinge binding region |
Hinge6 |
Yes |
EGFR(T790M) |
Hinge binding region |
Hinge6 |
Yes |
EPHB3 |
Hinge binding region |
Hinge5 |
No |
ERBB2 |
Hinge binding region |
Hinge6 |
No |
ERBB3 |
Glycine rich loop region, Roof region |
Glycineloop, Roof sheet |
No |
ERBB4 |
Hinge binding region |
Hinge6 |
No |
ERK1 |
DFG region |
DFG-1 |
No |
ERK2 |
DFG region |
DFG-1 |
No |
ERN1 |
DFG region, Hinge binding region |
DFG+2, Hinge2 |
No |
FAK |
Hinge binding region |
Hinge2 |
No |
FGFR1 |
Glycine rich loop region |
Glycineloop5 |
No |
FGFR2 |
Glycine rich loop region |
Glycineloop5 |
No |
FGFR3 |
Glycine rich loop region |
Glycineloop5 |
No |
FGFR3(G697C) |
Glycine rich loop region |
Glycineloop5 |
Yes |
FGFR4 |
Glycine rich loop region, Hing binding region |
Glycineloop5, Hinge1 |
No |
FGR |
Hinge binding region |
Hinge3 |
No |
FLT1 |
DFG region, Hinge binding region |
DFG-1, Hinge2 |
No |
FLT3 |
DFG region, Hinge binding region |
DFG-1, Hinge2, Hinge3 |
No |
FLT3(D835H) |
DFG region, Hinge binding region |
DFG-1, Hinge2, Hinge3 |
Yes |
FLT3(D835Y) |
DFG region, Hinge binding region |
DFG-1, Hinge2, Hinge3 |
Yes |
FLT3(ITD) |
DFG region, Hinge binding region |
DFG-1, Hinge2, Hinge3 |
Yes |
FLT3(K663Q) |
DFG region, Hinge binding region |
DFG-1, Hinge2, Hinge3 |
Yes |
FLT3(N841I) |
DFG region, Hinge binding region |
DFG-1, Hinge2, Hinge3 |
Yes |
FLT3(R834Q) |
DFG region, Hinge binding region |
DFG-1, Hinge2, Hinge3 |
Yes |
FLT3-autoinhibited |
DFG region, Hinge binding region |
DFG-1, Hinge2, Hinge3 |
No |
FLT4 |
DFG region, Hinge binding region |
DFG-1, Hinge2 |
No |
GAK |
DFG region, Hinge binding region |
DFG-1, Hinge2 |
No |
GCN2(Kin.Dom.2,S808G) |
Hinge binding region |
Hinge2 |
Yes |
GSK3A |
DFG region |
DFG-1 |
No |
GSK3B |
DFG region |
DFG-1 |
No |
HPK1 |
Gatekeeper, Hinge binding region |
GK-1, Hinge2 |
No |
HUNK |
Hinge binding region |
Hinge2 |
No |
IKK-alpha |
Hinge binding region |
Hinge2 |
No |
IKK-beta |
Hinge binding region |
Hinge2 |
No |
IKK-epsilon |
Hinge binding region |
Hinge2 |
No |
ITK |
Hinge binding region |
Hinge6 |
No |
JAK3(JH1domain-catalytic) |
Hinge binding region |
Hinge6 |
No |
JNK1 |
Hinge binding region |
Hinge7 |
No |
JNK2 |
Hinge binding region |
Hinge7 |
No |
JNK3 |
Hinge binding region |
Hinge7 |
No |
KIT |
DFG region, Hinge binding region |
DFG-1, Hinge2, Hinge3 |
No |
KIT(A829P) |
DFG region, Hinge binding region |
DFG-1, Hinge2, Hinge3 |
Yes |
KIT(D816H) |
DFG region, Hinge binding region |
DFG-1, Hinge2, Hinge3 |
Yes |
KIT(D816V) |
DFG region, Hinge binding region |
DFG-1, Hinge2, Hinge3 |
Yes |
KIT(L576P) |
DFG region, Hinge binding region |
DFG-1, Hinge2, Hinge3 |
Yes |
KIT(V559D) |
DFG region, Hinge binding region |
DFG-1, Hinge2, Hinge3 |
Yes |
KIT(V559D,T670I) |
DFG region, Hinge binding region |
DFG-1, Hinge2 |
Yes |
KIT(V559D,V654A) |
DFG region, Hinge binding region |
DFG-1, Hinge2 |
Yes |
KIT-autoinhibited |
DFG region, Hinge binding region |
DFG-1, Hinge2 |
No |
LKB1 |
Hinge binding region |
Hinge2, Hinge4 |
No |
LOK |
Hinge binding region |
Hinge2 |
No |
LZK |
Hinge binding region |
Hinge2 |
No |
MAP3K4 |
DFG region, Hinge binding region |
DFG+1, Hinge2 |
No |
MAP4K3 |
Gatekeeper, Hinge binding region |
GK-1, Hinge2 |
No |
MAP4K4 |
Hinge binding region |
Hinge2 |
No |
MAP4K5 |
Gatekeeper, Hinge binding region |
GK-1, Hinge2 |
No |
MAPKAPK2 |
Hinge binding region |
Hinge1 |
No |
MAPKAPK5 |
DFG region |
DFG-1 |
No |
MEK1 |
Gatekeeper, DFG region |
GK-1, DGF-1 |
No |
MEK2 |
Gatekeeper, DFG region |
GK-1, DGF-1 |
No |
MEK3 |
Gatekeeper, DFG region |
GK-1, DGF-1 |
No |
MEK4 |
Gatekeeper, DFG region |
GK-1, DGF-1 |
No |
MEK5 |
Gatekeeper, DFG region |
GK-1, DGF-1 |
No |
MEK6 |
Gatekeeper, DFG region |
GK-1, DGF-1 |
No |
MELK |
DFG region, Hinge binding region |
DFG+2, Hinge2 |
No |
MINK |
Hinge binding region |
Hinge2 |
No |
MKK7 |
DFG region, Hinge binding region |
DFG-1, Hinge6 |
No |
MKNK1 |
DFG region |
DFG-1 |
No |
MKNK2 |
DFG region |
DFG-1 |
No |
MRCKB |
DFG region |
DFG+2 |
No |
MST1 |
Hinge binding region |
Hinge2 |
No |
MST1R |
Hinge binding region |
Hinge3 |
No |
MST2 |
Hinge binding region |
Hinge2 |
No |
MYO3A |
Hinge binding region |
Hinge2 |
No |
MYO3B |
Hinge binding region |
Hinge2 |
No |
NDR1 |
DFG region |
DFG+2 |
No |
NDR2 |
DFG region |
DFG+2 |
No |
NEK1 |
Hinge binding region |
Hinge2 |
No |
NEK11 |
Hinge binding region |
Hinge2 |
No |
NEK2 |
Glycine rich loop region, Hing binding region |
Glycineloop2, Hinge2 |
No |
NEK3 |
Hinge binding region |
Hinge2 |
No |
NEK4 |
Hinge binding region |
Hinge2 |
No |
NEK5 |
Hinge binding region |
Hinge2 |
No |
NEK9 |
Hinge binding region |
Hinge2 |
No |
NIK |
DFG region |
DFG-1 |
No |
NLK |
DFG region |
DFG-1 |
No |
PAK1 |
DFG region |
DFG+2 |
No |
PAK2 |
DFG region |
DFG+2 |
No |
PAK3 |
DFG region |
DFG+2 |
No |
PAK4 |
DFG region |
DFG+2 |
No |
PAK6 |
DFG region |
DFG+2 |
No |
PDGFRA |
DFG region, Hinge binding region |
DFG-1, Hinge2 |
No |
PDGFRB |
DFG region, Hinge binding region |
DFG-1, Hinge2 |
No |
PKN1 |
DFG region |
DFG+2 |
No |
PKN2 |
DFG region |
DFG+2 |
No |
PLK1 |
Glycine rich loop region, Hing binding region |
Glycineloop2, Hinge2 |
No |
PLK2 |
Glycine rich loop region, Hing binding region |
Glycineloop2, Hinge2 |
No |
PLK3 |
Glycine rich loop region, Hing binding region |
Glycineloop2, Hinge2 |
No |
PLK4 |
Hinge binding region |
Hinge2 |
No |
PRKCD |
DFG region |
DFG+2 |
No |
PRKCE |
DFG region |
DFG+2 |
No |
PRKCI |
DFG region |
DFG+2 |
No |
PRKCQ |
DFG region |
DFG+2 |
No |
PRKD1 |
DFG region |
DFG-1 |
No |
PRKD2 |
DFG region |
DFG-1 |
No |
PRKD3 |
DFG region |
DFG-1 |
No |
PRKG1 |
Hinge binding region |
Hinge2 |
No |
PRKG2 |
Hinge binding region |
Hinge2 |
No |
PRKR |
Hinge binding region |
Hinge2 |
No |
PRP4 |
DFG region |
DFG-1 |
No |
RAF1 |
Hinge binding region |
Hinge2 |
Yes |
RIPK5 |
DFG region, Glycine rich loop region |
DFG+2, Glycineloop2 |
No |
ROCK1 |
DFG region |
DFG+2 |
No |
ROCK2 |
DFG region |
DFG+2 |
No |
RPS6KA4(Kin.Dom.2-C-terminal) |
Glycine rich loop region |
Glycineloop2 |
No |
RPS6KA5(Kin.Dom.2-C-terminal) |
Glycine rich loop region |
Glycineloop2 |
No |
RSK1(Kin.Dom.1-N-terminal) |
DFG region |
DFG-1 |
No |
RSK1(Kin.Dom.2-C-terminal) |
DFG region, Glycine rich loop region |
DFG-1, Glycineloop2 |
No |
RSK2(Kin.Dom.1-N-terminal) |
DFG region |
DFG-1 |
No |
RSK2(Kin.Dom.2-C-terminal) |
DFG region, Glycine rich loop region |
DFG-1, Glycineloop2 |
No |
RSK3(Kin.Dom.1-N-terminal) |
DFG region |
DFG-1 |
No |
RSK3(Kin.Dom.2-C-terminal) |
DFG region, Glycine rich loop region |
DFG-1, Glycineloop2 |
No |
RSK4(Kin.Dom.1-N-terminal) |
DFG region |
DFG-1 |
No |
RSK4(Kin.Dom.2-C-terminal) |
DFG region, Glycine rich loop region |
DFG-1, Glycineloop2 |
No |
S6K1 |
DFG region |
DFG+2 |
No |
SgK110 |
Hinge binding region |
Hinge4 |
No |
SGK2 |
DFG region |
DFG+2 |
No |
SGK3 |
DFG region |
DFG+2 |
No |
SLK |
Hinge binding region |
Hinge2 |
No |
STK33 |
Hinge binding region |
Hinge2 |
No |
STK35 |
Hinge binding region |
Hinge2 |
No |
TAK1 |
DFG region |
DFG-1 |
No |
TAOK1 |
Hinge binding region |
Hinge2 |
No |
TAOK2 |
Hinge binding region |
Hinge2 |
No |
TAOK3 |
Hinge binding region |
Hinge2 |
No |
TBK1 |
Hinge binding region |
Hinge2, Hinge4 |
No |
TEC |
Hinge binding region |
Hinge6 |
No |
TGFBR2 |
DFG region |
DFG-1 |
No |
TLK1 |
Hinge binding region |
Hinge2 |
No |
TLK2 |
Hinge binding region |
Hinge2 |
No |
TNIK |
Hinge binding region |
Hinge2 |
No |
TTK |
Hinge binding region |
Hinge1 |
No |
TXK |
Hinge binding region |
Hinge6 |
No |
ULK1 |
Hinge binding region |
Hinge2 |
No |
ULK2 |
Hinge binding region |
Hinge2 |
No |
ULK3 |
Hinge binding region |
Hinge2 |
No |
VEGFR2 |
DFG region, Hinge binding region |
DFG-1, Hinge2 |
No |
WEE1 |
Hinge binding region |
Hinge2 |
No |
WEE2 |
Hinge binding region |
Hinge2 |
No |
WNK1 |
Glycine rich loop region |
Glycineloop |
No |
WNK3 |
Glycine rich loop region |
Glycineloop |
No |
ZAK |
DFG region, Glycine rich loop region |
DFG-1, Glycineloop1 |
No |