Validated Cell-Based Assays for Rapid Screening and Functional Characterization of Therapeutic Monoclonal Antibodies

Validated Cell-Based Assays for Rapid Screening and Functional Characterization of Therapeutic Monoclonal Antibodies
Version:
V12013

File Name/Number:
DOT2013

Year:
2013

Monoclonal antibodies (MAbs) represent one of the fastest growing classes of biotherapeutic molecules today. While many technologies exist for generating and panning large collections of antibody fragments, there is a clear need for tools that can reliably detect both the binding and functional activity of a monoclonal antibody in a fast, reproducible and cost effective manner. This requires validated and sensitive cell-based assays that provide a target-specific response and have a high tolerance for serum, cellular and bacterial extracts.