GPCR Reference Guide

GPCR Reference Guide
Version:
092215

File Name/Number:
20174

Year:
2015

As more is learned about the intricacies of GPCR signaling, the harder it becomes to accurately describe ligand activity using a single functional readout. Access to the same GPCR target in different technology formats allows multiple signaling pathways to be assayed in parallel using the same robust, reliable and screening-friendly chemiluminescent format. Using a combination of technology platforms enables the identification of G-protein or beta-arrestin biased ligands and provides a unique opportunity to determine mechanism of action and compare small molecule compounds or biologic ligands (e.g. antibodies, peptides, proteins) potencies in vitro. DiscoveRx offers an industry leading portfolio of over 660 naturally coupled GPCR cell lines utilizing its Enzyme Fragment Complementation (EFC) technology.  This GPCR Reference Guide highlights the DiscoveRx technology and assays available for GPCR research. Assay data and references included in this guide is only representative, thus please refer to our website for the most up-to-date data.