[EUROFINS GPCR SYMPOSIUM 2022] How to leverage new AI technologies alongside traditional HTS to identify better hit compounds for GPCRs
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- EUROFINS GPCR SYMPOSIUM
G protein-coupled receptors (GPCRs) constitute the largest class of transmembrane proteins in the human genome and play important roles in disease pathogenesis, and therefore are one of the largest classes of drug targets including blockbuster drugs such as Cimetidine, Olanzapine and Clopidogrel. Over 100 GPCRs in the human genome are classified as orphans: receptors whose endogenous ligands and biological function remain unknown, thus these targets represent promising, yet challenging targets for drug discovery.