Insights into GPCR Drug Discovery & Development

Insights into GPCR Drug Discovery & Development



Explore GPCR-Ligand Interactions & Signaling Pathways with Binding & Functional Assays


G protein-coupled receptors (GPCRs) represent the largest family of validated therapeutic targets with over 800 known human GPCRs. Their physiological and pathological involvements are vast, ranging from regulation of hunger, metabolism, homeostasis to the development of fetal structures, and from roles in cardiovascular disorders, cancer, diabetes to neurological to rare diseases. Therapeutics targeting GPCRs represent over 40% of all currently marketed drug therapeutics acting on GPCRs either directly or indirectly.