The Druggable GPCRome

The Druggable GPCRome

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DiscoveRx offers an industry-leading portfolio of over 600 naturally coupled human and ortholog G-protein coupled receptor (GPCR) cell lines designed to detect GPCR signaling through 2nd messenger activation, b-arrestin recruitment and receptor internalization. Access to the same GPCR target in different technology formats allows multiple signaling pathways to be assayed in parallel for ligand bias studies using the same robust, reliable and high-throughput friendly chemiluminescent format. With our large collection of GPCR assays, DiscoveRx provides ultimate flexibility choosing from several screening platforms to analyze small molecules compounds and biologics (e.g. antibodies, peptides, proteins).