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Webinar: Discovery of Bacterial Effectors in the Human Microbiome and Isolation of a GPCR G2A/GPR132 Agonist

Kinase dendrogram

Wednesday, August 16, 2017

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(25-minute seminar, 5-minute Q&A)

Presenter: Louis Cohen, MD, MS, Assistant Professor, Icahn School of Medicine at Mount Sinai

The human microbiome is believed to have an important role in maintaining health or perpetuating disease. Little is known, however, about specific mechanisms through which human-associated microbiota are able to affect host cellular functions. G protein-coupled receptors (GPCRs) are the most common target for medical therapeutics due to their ability to regulate a wide variety of cellular functions. It is likely that human microbiota affects host physiology which may be mediated in part through GPCRs.

In this webinar, Dr. Cohen will demonstrate his approach to studying GPCRs and their impact on the human microbiome.

What will be covered?

  • The role of GPCRs in regulating host-microbial interactions
  • How to identify microbial metabolites that modulate GPCR functions
  • A case study on defining host-microbial interaction and therapeutic potential of N-acyl amides, bacterial metabolites that activate GPR132/G2A

Who should attend?

  • GPCR drug discovery researchers
  • Pharmacologists and cell biologists working in life science labs
  • Basic research scientists