Thursday, March 9, 2017
Prof. Gavril Pasternak
Laboratory Head, Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center
Opioid receptors are among the most well-known GPCRs that regulate the transmission and perception of pain. Clinical management of severe pain depends heavily on opioids acting through μ-opioid receptors (MORs) encoded by the OPRM1 gene, which undergoes extensive alternative splicing, generating an array of splice variants.
In this webinar, Professor Pasternak will describe a set of mutant mouse models developed to investigate the importance of OPRM1 5’ and 3’ splicing and the role of their distal C-terminal tails in mediating complex morphine actions. These models revealed major behavioral and transduction differences, including biased signaling and β-arrestin recruitment, among the 3’ splice variants and the drugs tested.
What will be covered?
- Overview of the mu opioid receptor signaling
- GPCR splicing, using OPRM1 as an example
- Region and cell specific splicing
- Functional consequences of 5’ splicing
- Functional consequences of 3’ splicing
Who should attend?
- Scientists working in GPCR research and drug discovery
- Scientists with focus on morphine/opioids pharmacology, mechanism of action, and developing drug candidates
- Assay development drug discovery scientists